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Disease resistant glow in the dark cats! (Coming soon to a theatre near you)

TheClawTheClaw Registered User regular
edited September 2011 in Debate and/or Discourse
So I saw this in the news. Thought it was interesting. I'm curious what other people's opinions are about genetically altering animals. Or just genetic altering in general.

http://www.sciencenews.org/view/generic/id/334271/description/Cats_engineered_for_disease_resistance

When have power, how get skill? - Me
TheClaw on
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    ElJeffeElJeffe Moderator, ClubPA mod
    Oh man, I want a glow in the dark cat.

    I submitted an entry to Lego Ideas, and if 10,000 people support me, it'll be turned into an actual Lego set!If you'd like to see and support my submission, follow this link.
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    TheClawTheClaw Registered User regular
    Soon ElJeffe...
    soon...

    When have power, how get skill? - Me
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    HeirHeir Ausitn, TXRegistered User regular
    ElJeffe wrote:
    Oh man, I want a glow in the dark cat.

    This is pretty much went through my mind at first as well. Sure I should be thinking "Wow, yay for science." Or, "I wonder what the ethical implications of this will be?"

    Instead, I thought "You're a kitty!"

    camo_sig2.png
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    DelzhandDelzhand Hard to miss. Registered User regular
    Transgenic humans: wrong
    Transgenic kittens: adorable

    Hey, I'm entitled to a little cognitive dissonance once in a while. It's not like I'm a perfectly rational actor regarding cats anyway.

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    BurtletoyBurtletoy Registered User regular
    edited September 2011
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    ElJeffeElJeffe Moderator, ClubPA mod
    Yes, Burtletoy, but these are kitties.

    I submitted an entry to Lego Ideas, and if 10,000 people support me, it'll be turned into an actual Lego set!If you'd like to see and support my submission, follow this link.
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    DelzhandDelzhand Hard to miss. Registered User regular
    Oh! Oh! I got it!

    My kitten is augmented

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    BurtletoyBurtletoy Registered User regular
    ElJeffe wrote:
    Yes, Burtletoy, but these are kitties.

    Are puppies that different?

    gpup.jpg

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    DrukDruk Registered User regular
    Why are that kitty's eyes black? Is it because the genetic engineering process removed its soul?

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    ArchArch Neat-o, mosquito! Registered User regular
    edited September 2011
    ElJeffe wrote:
    Yes, Burtletoy, but these are kitties.

    ...we made "glow in the dark cats" back in 2007.

    Not saying it isn't interesting, but it must have been a slow science news day if they want to recycle this...I haven't delved into the story too deeply but I don't know what is so different or special about this new GFP kitty as opposed to the old ones.

    GFP is a pretty common reporter gene in eukaryotes that we use to make it easier to identify whether your transgene experiment worked so you don't have to run a PCR every time- you just shine a UV light on them (and with some GFP, you don't even need that much!). I think my lab has some GFP Tribolium beetles, but I don't work with them.

    Obviously, I am all in favor of any sort of transgenic experiment, although the new hotness right now isn't retroviral insertion, it is RNAi.

    Personally I am sad that these things don't actually light up like fireflies, although that is a more complex system, and not one I think can be easily transfected into whole new organism.

    Still, I wouldn't mind seeing more transgenic animals on the consumer market- I think it could go a long way towards easing people's minds about transgenic experiments in general.

    Arch on
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    CptHamiltonCptHamilton Registered User regular
    I'd totally adopt a transgenic kitten. Probably not glow in the dark, since my cats keep me up at night enough as it is, but one that was engineered to resist the various common cat problems (FIV, feline leukemia, herpes, and round worm, off the top of my head) would be nice. If they could somehow be simultaneously fluffy and not shed like mad and have waste products that smell like lilac that'd be cool, too. And racing stripes.

    PSN,Steam,Live | CptHamiltonian
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    CommunistCowCommunistCow Abstract Metal ThingyRegistered User regular
    edited September 2011
    Screw the kitties; I want a tame fox bred by Russian scientists. http://www.sibfox.com/
    Environmentalists and scientists at one of the breeding farms in Siberia have created a new version of the silver fox by allowing only the friendliest animals from each generation to breed. The program was started in 1959 by Dr. Belyaev who believed that the key factor for the domestication of dogs was neither size nor reproduction but behavior. He started experiments with a population of 100 vixens and 30 male foxes from a fur farm in Estonia. Belyaev domesticated a population of foxes and put them under strong selection pressure for inherent tameness. Only 5% of the most disciplined offspring were selected for further breeding. It took 35 generations and 45,000 foxes to select this trait. To keep environmental influences to a minimum, the foxes did not receive any special training, and their contact with humans was limited to brief behavioral tests.

    CommunistCow on
    No, I am not really communist. Yes, it is weird that I use this name.
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    ForarForar #432 Toronto, Ontario, CanadaRegistered User regular
    edited September 2011
    It seems like every time we make something that "glows in the dark" it's usually with the caveat that it requires special lighting.*

    Damnit I want animals that are actually bioluminescent!

    Edit: I know there are exceptions to this statement.

    Forar on
    First they came for the Muslims, and we said NOT TODAY, MOTHERFUCKER!
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    adytumadytum The Inevitable Rise And FallRegistered User regular
    Let's see you hide now, kitty.

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    redxredx I(x)=2(x)+1 whole numbersRegistered User regular
    Like, bioluminescence, IIRC, requires actually mixing a couple different chemicals. There isn't one protein that makes lighting bugs glow. Not only do you need to make more chemicals, they need somewhere they can do their work and places where they can be stored before that.

    That's a hell of a lot harder than sticking a single gene into an animal's DNA strand.

    They moistly come out at night, moistly.
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    TheClawTheClaw Registered User regular
    I'm kind of ambivalent about genetic alteration in general, but what actually scares me is when I read stories like Malaysia releasing genetically altered mosquitoes into the wild.

    http://www.dailymail.co.uk/news/article-1350708/Genetically-modified-mosquitoes-released-Malaysia-sparks-fears-uncontrollable-new-species.html

    To me that stuff sounds dangerous. Of course there is a side of me however that wonders what happens when we mix something like that with something like this:

    http://vigilantcitizen.com/latestnews/“zombie”-ants-fall-victim-to-mind-control-fungus/

    So genetic altering + mind controling fungus = ?

    Welcome to the apocolypse *DUN DUN DUUUUUUUUN*

    When have power, how get skill? - Me
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    BurtletoyBurtletoy Registered User regular
    TheClaw wrote:
    I'm kind of ambivalent about genetic alteration in general, but what actually scares me is when I read stories like Malaysia releasing genetically altered mosquitoes into the wild.

    http://www.dailymail.co.uk/news/article-1350708/Genetically-modified-mosquitoes-released-Malaysia-sparks-fears-uncontrollable-new-species.html

    To me that stuff sounds dangerous. Of course there is a side of me however that wonders what happens when we mix something like that with something like this:

    http://vigilantcitizen.com/latestnews/“zombie”-ants-fall-victim-to-mind-control-fungus/

    So genetic altering + mind controling fungus = ?

    Welcome to the apocolypse *DUN DUN DUUUUUUUUN*

    Do you eat strawberries? Genetically altered with fish proteins to resist freezing
    Do you eat potatoes? Genetically altered with BT Toxin to resist pests.

    This shit is really really common.

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    Fallout2manFallout2man Vault Dweller Registered User regular
    Forar wrote:
    It seems like every time we make something that "glows in the dark" it's usually with the caveat that it requires special lighting.*

    Damnit I want animals that are actually bioluminescent!

    Edit: I know there are exceptions to this statement.

    This, this right here. I've tripped over more than a few I'd love any future cat of mine to actually glow in the dark at night. I really think we need to invent some sort of new word to describe this current crop of animals since it's really like when they take a blacklight into a motel room to look for all the stains that don't wash out. Very different from introducing bioluminescence into a complex living organism that had nothing like it before.

    On Ignorance:
    Kana wrote:
    If the best you can come up with against someone who's patently ignorant is to yell back at him, "Yeah? Well there's BOOKS, and they say you're WRONG!"

    Then honestly you're not coming out of this looking great either.
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    ArchArch Neat-o, mosquito! Registered User regular
    redx wrote:
    Like, bioluminescence, IIRC, requires actually mixing a couple different chemicals. There isn't one protein that makes lighting bugs glow. Not only do you need to make more chemicals, they need somewhere they can do their work and places where they can be stored before that.

    That's a hell of a lot harder than sticking a single gene into an animal's DNA strand.

    Which is why I gave the caveat that it is a "more complex system"

    Let me lay it out- I am working in insect molecular biology right now.

    If anyone could make something with firefly level bioluminescence, it would be me

    Unfortunately, it ain't possible, and thus we are all a bit sad

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    TheClawTheClaw Registered User regular
    edited September 2011
    Burtletoy wrote:
    TheClaw wrote:
    I'm kind of ambivalent about genetic alteration in general, but what actually scares me is when I read stories like Malaysia releasing genetically altered mosquitoes into the wild.

    http://www.dailymail.co.uk/news/article-1350708/Genetically-modified-mosquitoes-released-Malaysia-sparks-fears-uncontrollable-new-species.html

    To me that stuff sounds dangerous. Of course there is a side of me however that wonders what happens when we mix something like that with something like this:

    http://vigilantcitizen.com/latestnews/“zombie”-ants-fall-victim-to-mind-control-fungus/

    So genetic altering + mind controling fungus = ?

    Welcome to the apocolypse *DUN DUN DUUUUUUUUN*

    Do you eat strawberries? Genetically altered with fish proteins to resist freezing
    Do you eat potatoes? Genetically altered with BT Toxin to resist pests.

    This shit is really really common.

    I know. That's why I'm kind of on the fence about it (just my opinion on the matter). I mean scientifically I think it's interesting. I think the goal is reasonable if you think about it helping people. The geek in me thinks it's pretty rad to wonder where it could lead. But seeing as how it's so common, and seeing as how, given mankind's nature, it will inevitably continue and grow to other areas, I find it difficult to not be a little wary. Human beings (and governments especially), don't exactly have the greatest track record when it comes to not abusing science (or anything really). Sort of the same way some people view guns: Cool, but also very dangerous. It's a complex issue, hence the post.

    TheClaw on
    When have power, how get skill? - Me
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    L Ron HowardL Ron Howard The duck MinnesotaRegistered User regular
    Druk wrote:
    Why are that kitty's eyes black? Is it because the genetic engineering process removed its soul?

    You cannot remove that which was never there in the first place.

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    Hahnsoo1Hahnsoo1 Make Ready. We Hunt.Registered User regular
    Here's a much better pic of the kittens in the OP (spoilered for huge and OMG CUTE!):
    sn-cats-thumb-800xauto-10980.jpg

    So cute! You're a kitty!

    8i1dt37buh2m.png
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    override367override367 ALL minions Registered User regular
    edited September 2011
    When can I get one of these

    http://www.youtube.com/watch?v=NBfi8OEz0rA

    override367 on
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    TheClawTheClaw Registered User regular

    Lol, awesome. I need a house honey badger. I'll give it a badger house in my front yard and put a sign that says "Beware of Badger"

    When have power, how get skill? - Me
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    BurtletoyBurtletoy Registered User regular
    Right after I get one of these

    http://www.youtube.com/watch?v=xVxxLYmypv8

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    ShanadeusShanadeus Registered User regular
    edited September 2011
    Oh my god that is an adorable kitten!

    I'm all for genetic manipulation of animals and plants.
    Imagine how helpful that glow in the dark thingy would be for searching for children that are missing.
    Arch wrote:
    redx wrote:
    Like, bioluminescence, IIRC, requires actually mixing a couple different chemicals. There isn't one protein that makes lighting bugs glow. Not only do you need to make more chemicals, they need somewhere they can do their work and places where they can be stored before that.

    That's a hell of a lot harder than sticking a single gene into an animal's DNA strand.

    Which is why I gave the caveat that it is a "more complex system"

    Let me lay it out- I am working in insect molecular biology right now.

    If anyone could make something with firefly level bioluminescence, it would be me

    Unfortunately, it ain't possible, and thus we are all a bit sad
    Hmm, what about creating a modified firefly that seek out and live in tiny, tiny subdermal pockets under the skin of an animal modified to secret extra sugars (or whatever fireflies need) through their sweat?

    ...

    Probably a good thing I'm not a geneticist.

    Shanadeus on
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    JustinSane07JustinSane07 Really, stupid? Brockton__BANNED USERS regular
    If my cat glowed in the dark, I would be extremely fucking frightened all the time.

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    Phoenix-DPhoenix-D Registered User regular
    Arch wrote:
    ElJeffe wrote:
    Yes, Burtletoy, but these are kitties.

    ...we made "glow in the dark cats" back in 2007.

    Not saying it isn't interesting, but it must have been a slow science news day if they want to recycle this...I haven't delved into the story too deeply but I don't know what is so different or special about this new GFP kitty as opposed to the old ones.

    The glow in the dark isn't the point this time, its just what people are fixated on. The point is injecting genes to help with FIV resistance...the glow in the dark genes got attached as a "Yep, the genes got delivered" visual cue.

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    BurtletoyBurtletoy Registered User regular
    edited September 2011
    Shanadeus wrote:
    Hmm, what about creating a modified firefly that seek out and live in tiny, tiny subdermal pockets under the skin of an animal modified to secret extra sugars (or whatever fireflies need) through their sweat?

    ...

    Probably a good thing I'm not a geneticist.

    What you are looking for is bioluminescent bacteria, which is how lots of bioluminescent animals glow, already.

    The so-called "symbiotic" relationship

    Burtletoy on
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    ShanadeusShanadeus Registered User regular
    Burtletoy wrote:
    Shanadeus wrote:
    Hmm, what about creating a modified firefly that seek out and live in tiny, tiny subdermal pockets under the skin of an animal modified to secret extra sugars (or whatever fireflies need) through their sweat?

    ...

    Probably a good thing I'm not a geneticist.

    What you are looking for is bioluminescent bacteria, which is how lots of bioluminescent animals glow, already.

    The so-called "symbiotic" relationship
    That sounds so much simpler.

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    ElJeffeElJeffe Moderator, ClubPA mod
    I'd totally adopt a transgenic kitten.

    Me too. I consider myself open-minded and would completely support the kitten's chosen lifestyle.

    I submitted an entry to Lego Ideas, and if 10,000 people support me, it'll be turned into an actual Lego set!If you'd like to see and support my submission, follow this link.
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    shrykeshryke Member of the Beast Registered User regular
    Hahnsoo1 wrote:
    Here's a much better pic of the kittens in the OP (spoilered for huge and OMG CUTE!):
    sn-cats-thumb-800xauto-10980.jpg

    So cute! You're a kitty!

    SQUEEEEE!!!!!

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    Witch_Hunter_84Witch_Hunter_84 Registered User regular
    I thought cats were already largely resistant to the feline immunodeficiency virus?

    If you can't beat them, arrange to have them beaten in your presence.
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    BlurblBlurbl -_- Registered User regular
    Wouldn't being glow in the dark completely fuck up a cats hunting skills? I'm all for genetic engineering to increase resistance to diseases etc, but I'd draw the line at changing appearances for the same reason I disagree with handbag dogs, it's just changing shit for the sake of vanity.

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    BurtletoyBurtletoy Registered User regular
    edited September 2011
    Blurbl wrote:
    Wouldn't being glow in the dark completely fuck up a cats hunting skills? I'm all for genetic engineering to increase resistance to diseases etc, but I'd draw the line at changing appearances for the same reason I disagree with handbag dogs, it's just changing shit for the sake of vanity.

    That isn't what is happening. Try reading the linked article.

    And, hunting skills for a household pet? What?

    Burtletoy on
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    dojangodojango Registered User regular
    Given that most domesticated cats hunt by jumping on their owners faces until they get fed, glowing in the dark would make them that much harder to ignore. As far as wild cats... well, sure, but I doubt that these cats are going to be released into the wild. They might interbreed with feral cats, though, which could cause problems.

    Also, handbag dogs aren't made through advanced genetic tinkering, just good ol' fashioned animal husbandry, you know, what we've been doing for 10,000 years.

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    BurtletoyBurtletoy Registered User regular
    And they don't even glow in the dark!

    The glow under a specific florescent light!

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    dlinfinitidlinfiniti Registered User regular
    what we need is
    chameleon + cat
    you will never feel safe inside your own home again

    AAAAA!!! PLAAAYGUUU!!!!
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    Zilla360Zilla360 21st Century. |She/Her| Trans* Woman In Aviators Firing A Bazooka. ⚛️Registered User regular
    Blurbl wrote:
    Wouldn't being glow in the dark completely fuck up a cats hunting skills? I'm all for genetic engineering to increase resistance to diseases etc, but I'd draw the line at changing appearances for the same reason I disagree with handbag dogs, it's just changing shit for the sake of vanity.
    The maximum excitation wavelength for the eGFP protein is 488 nm, visible light for humans is 390nm to 750nm. Shine a blue (UV) light on these & use filters to block the blue light from your eyes, which will allow you to see the 'glow'. You won't see it otherwise.

    Vanity? Humans have been selecting for traits in other species for thousands of years, this is simply an acceleration of that process of trait selection.
    Although, granted, we've never had jellyfish mate with mammals before...

    There are species of dogs that exist today (regardless of genetic engineering), that are completely reliant on humans, as they are unable to hunt as their ancestors did. They can't survive otherwise.

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    Zilla360Zilla360 21st Century. |She/Her| Trans* Woman In Aviators Firing A Bazooka. ⚛️Registered User regular
    edited September 2011
    Also, if you live in the U.S, these transgenic fish are legal to buy, except for California:

    http://www.youtube.com/watch?v=vAyJuKq2aWA&feature=player_embedded

    Zilla360 on
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