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Que veux-tu, [chat]? Happy May Day!

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Posts

  • InquisitorInquisitor Registered User regular
    This bath is amazing. Hot bath on cold day best thing.

  • FeralFeral Who needs a medical license when you've got style? Registered User regular
    spool32 wrote: »
    does it decrease sensation in general?

    It's not unheard of.

    Like any neuro drug not everybody sees the same side effects, and a drug that is completely intolerable in one person can be somebody else's miracle drug.

    I wrote this several posts up but it might have gotten lost in neurospam:
    Feral wrote: »
    How about Lyrica?

    Lyrica and Neurotin both work on the GABA system though in unknown ways and they tend to work well on neuropathic pain; however the side effect profiles are comparable to CNS depressants - drowsiness, slowed reflexes, dizziness, blurred vision, etc. Not everybody experiences those side effects, but they're pretty common, so you might have to make a choice whether you'd risk a little more "brain fog" in exchange for reduced pain.

    Also, this is spoilered for being a scary side effect that only happens in a tiny minority of people:
    Spoiler:

    every person who doesn't like an acquired taste always seems to think everyone who likes it is faking it. it should be an official fallacy.
    the "no true scotch, man" fallacy.
  • Disco TerrierDisco Terrier Registered User regular
    Omagaaaah I'm in the end of Avatar season 1 you guys

    I'm excited you guys

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  • surrealitychecksurrealitycheck NONSTOP INFINITE CLIMAX POSTING you must go on i cant go on ill go onRegistered User regular
    the overwhelming feeling i get about all this shit in general is that the more i read the more i know that i have no clue, and neither does anybody else

    it is a good feeling

    ps good luck doing rational drug design for neurological conditions :x

    obF2Wuw.png
  • FeralFeral Who needs a medical license when you've got style? Registered User regular
    heh

    neurospam

    sounds like a Black ICE from Shadowrun

    every person who doesn't like an acquired taste always seems to think everyone who likes it is faking it. it should be an official fallacy.
    the "no true scotch, man" fallacy.
  • GooeyGooey Registered User regular
    Ludious wrote: »
    So what is Yo Gaba Gaba

    it is a double transmitter

    i thought that was a Ramones thing

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  • ronyaronya Arrrrrrf. the ivory tower's basementRegistered User regular
    to pull up wheat or not to pull up wheat

  • DasUberEdwardDasUberEdward Registered User regular
  • surrealitychecksurrealitycheck NONSTOP INFINITE CLIMAX POSTING you must go on i cant go on ill go onRegistered User regular
    btw winky i edited my last post on the last page to include an analogy to gaba idk if you saw it because i didnt think of it immediately

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  • FeralFeral Who needs a medical license when you've got style? Registered User regular
    the overwhelming feeling i get about all this shit in general is that the more i read the more i know that i have no clue, and neither does anybody else

    it is a good feeling

    ps good luck doing rational drug design for neurological conditions :x

    Prozac was the first approved drug developed from rational drug design, actually.

    All rational drug design does is go, "We want to target a specific receptor." (Or enzyme, or protein.) "Let's find a molecule that fits that receptor!"

    Knowing why that receptor does what it does is a different matter entirely.

    We're still a step ahead from where we were before Julius Axelrod. We gave people drugs without even knowing what receptors they interacted with. Now at least some of the time we have a general idea of what receptors the drugs are interacting with, just not why doing stuff to those receptors does what it does.

    every person who doesn't like an acquired taste always seems to think everyone who likes it is faking it. it should be an official fallacy.
    the "no true scotch, man" fallacy.
  • WinkyWinky Frog Rammer Registered User regular
    edited May 2012
    if it was because of its dopamine agonism youd see the same thing with bromocriptine

    and moreover, remember the effect persists indefinitely

    so it would need to be emulatable with any other strong dopamine agonist, which it isnt

    Right, I was wondering if it was somehow particularly strong among agonists. Though, I'm assuming here that it might be somehow stronger than just having more dopamine itself (since that's what you're doing with reuptake inhibitors/etc).

    Maybe it could be somehow breaking the receptor? Like it leaves the receptor in a more trigger-happy conformation or something? I don't know how long that would last, though. Actually somewhat related, since you would know: How often are dopamine receptors replaced? Are they constantly degrading and the neuron is constantly adding new ones, or do they hang out for a while?

    Winky on
    Play Super Smush wit me: 1006-0814-0691
  • EchoEcho staring is caring Super Moderator, Moderator mod
    where is the meat

    It's not a meat salad!

  • DasUberEdwardDasUberEdward Registered User regular
    i wonder why i thought this was great

    200px-Frog_and_toad_cover.jpg

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  • spool32spool32 Contrary Library Registered User regular
    So, naltrexone. What is bad about it?

  • WinkyWinky Frog Rammer Registered User regular
    edited May 2012
    if it was because of its dopamine agonism youd see the same thing with bromocriptine

    and moreover, remember the effect persists indefinitely

    so it would need to be emulatable with any other strong dopamine agonist, which it isnt

    my feeling is that we literally do not have enough knowledge to go for a proper mechanism

    it feels like a receptor variation thing... have you ever looked at the variants of the gaba receptor?

    it has a shit load of subunits, with a basic operating set and others that it swaps in and out

    alcohol has its particular effects because it fucks with the gamma subunit that is only present on a subpopulation of receptors

    you could not understand its effects if you assumed it hit every gaba receptor everywhere

    Good point.

    I've yet to get familiar with all the different subtypes of dopamine receptors.

    Hell, it was only just now that I found out there were significantly many past D4.

    Winky on
    Play Super Smush wit me: 1006-0814-0691
  • ThomamelasThomamelas “Three films a day, three books a week and records of great music would be enough to make me happy to the day I die.” Registered User regular
    Feral wrote: »
    heh

    neurospam

    sounds like a Black ICE from Shadowrun

    I could see that. The side effects from it cause the user to have the uncontrollable urge to sign up their handle for a companies marketing message. Makes it a bit more grey then black.

  • RiemannLivesRiemannLives Registered User regular
    Thomamelas wrote: »
    Echo wrote: »
    DoctorArch wrote: »
    I really want to get the A-10 Warthog simulator on sale at Steam but I know I won't play it anytime soon. I just have such a huge mancrush on the A-10.

    "Here's a gun. Let's build an aircraft around it."

    As crazy as the A-10 is, I think the design meeting for the AC-130H tops it. "Fuck it, we've got some 105mm howitzers sitting around, lets put one of those on a fucking plane!"

    the way the A-10 turned out though is one of the bigger successes of military hardware. Those things are cheap to build, actually acomplish a needed role (close ground support as opposed to stupid shit like air superiority fighters) and are extrememly tough and well armored.

    If it weren't for stupid funding rules designed to keep the services from spending all their time sabotaging each other they should replace every attack helicoper in service with an A10.

  • surrealitychecksurrealitycheck NONSTOP INFINITE CLIMAX POSTING you must go on i cant go on ill go onRegistered User regular
    ok, amend that to "good" rational drug design

    you dig

    re dopamine receptors:

    hours

    they do not persist long individually

    but youd be altering the mechanisms that led to their turnover, not the receptor quantity itself...

    obF2Wuw.png
  • surrealitychecksurrealitycheck NONSTOP INFINITE CLIMAX POSTING you must go on i cant go on ill go onRegistered User regular
    edited May 2012
    what is bad about naltrexone?

    gastrointestinal stuff mainly

    its not hugely dangerous especially if taken at low doses

    winky if you're interested in dopamine receptor ubiquitination start here and dig through refs

    http://www.jbc.org/content/283/17/11083.full

    surrealitycheck on
    obF2Wuw.png
  • TL DRTL DR Registered User regular
    Feral wrote: »
    heh

    neurospam

    sounds like a Black ICE from Shadowrun

    Like someone's Facebook getting hacked. Your friend decks into the wrong corporate subnet and from then on will periodically shout about free credit reports

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  • spool32spool32 Contrary Library Registered User regular
    what is bad about naltrexone?

    gastrointestinal stuff mainly

    its not hugely dangerous especially if taken at low doses

    That study you posted is quite promising. He says he's recruiting for a larger study to be completed in 2009, but I can find no more info and no email address to contact the Drs. involved.

    I bet my GP would write for it, if we knew more about how to go about trying.

  • EchoEcho staring is caring Super Moderator, Moderator mod
  • ronyaronya Arrrrrrf. the ivory tower's basementRegistered User regular
    I am too used to a government that responds to the specter of civil resistance by raising the stakes rather than backing down and counter-resisting via appeal to the public, as seems to be what people aim for here. Hmm.

  • FeralFeral Who needs a medical license when you've got style? Registered User regular
    edited May 2012
    ok, amend that to "good" rational drug design

    you dig

    Oh yeah we totally agree on this. "Rational drug design" isn't (necessarily) all that rational.

    Feral on
    every person who doesn't like an acquired taste always seems to think everyone who likes it is faking it. it should be an official fallacy.
    the "no true scotch, man" fallacy.
  • EchoEcho staring is caring Super Moderator, Moderator mod
    The recoil force of the GAU-8/A[14] is 10,000 pounds-force (45 kN),[3] which is slightly more than the output of one of the A-10's two TF34 engines (9,065 lbf / 40.3 kN each).[15] While this recoil force is significant, in practice cannon fire only slows the aircraft a few miles per hour.

  • surrealitychecksurrealitycheck NONSTOP INFINITE CLIMAX POSTING you must go on i cant go on ill go onRegistered User regular
    i do not know american doctor prescription rules but if you could make the case for limited off-label prescription i cant see him making a huge fuss, especially if you show him some decent evidence

    obF2Wuw.png
  • bloodyroarxxbloodyroarxx Registered User regular
  • WinkyWinky Frog Rammer Registered User regular
    God, if I could get ahold of all these experimental D4 receptor selective agonists I would be popping them like candy.

    Also, it is blowing my mind how many of them were developed as treatment for sexual dysfunction and not, you know, schizophrenia.

    Play Super Smush wit me: 1006-0814-0691
  • japanjapan Registered User regular
    ronya wrote: »
    I am too used to a government that responds to the specter of civil resistance by raising the stakes rather than backing down and counter-resisting via appeal to the public, as seems to be what people aim for here. Hmm.

    What prompted this observation?

  • FeralFeral Who needs a medical license when you've got style? Registered User regular
    Like...

    maybe you're doing rational drug design to make a new antiviral and you've mapped exactly how the viral RNA is translated into a specific protein on the viral sheath and this protein does not appear anywhere in mammals so you want to create a drug that breaks down just that protein.

    That's pretty rational. You have a pretty exhaustive picture of how that drug is going to work.

    Making a new GABA agonist because GABA agonists help pain... somehow...

    Pharma companies will call that "rational drug design" as well even though it's completely different in nature.

    every person who doesn't like an acquired taste always seems to think everyone who likes it is faking it. it should be an official fallacy.
    the "no true scotch, man" fallacy.
  • WinkyWinky Frog Rammer Registered User regular
    what is bad about naltrexone?

    gastrointestinal stuff mainly

    its not hugely dangerous especially if taken at low doses

    winky if you're interested in dopamine receptor ubiquitination start here and dig through refs

    http://www.jbc.org/content/283/17/11083.full

    Oh shit yes this is exactly the stuff I want. The more I can learn about D4 in particular the better.

    Play Super Smush wit me: 1006-0814-0691
  • ronyaronya Arrrrrrf. the ivory tower's basementRegistered User regular
    japan wrote: »
    ronya wrote: »
    I am too used to a government that responds to the specter of civil resistance by raising the stakes rather than backing down and counter-resisting via appeal to the public, as seems to be what people aim for here. Hmm.

    What prompted this observation?

    The GM wheat thing.

  • FeralFeral Who needs a medical license when you've got style? Registered User regular
    edited May 2012
    i do not know american doctor prescription rules but if you could make the case for limited off-label prescription i cant see him making a huge fuss, especially if you show him some decent evidence

    In the US, as long as the drug is not

    1) controlled
    or
    2) discouraged for that particular offlabel use by the FDA (which is rare)
    or
    3) contraindicated for some medical reason

    then physicians can prescribe it for offlabel use and it's not a big deal.

    Off label prescriptions aren't terribly rare in the US.

    Feral on
    every person who doesn't like an acquired taste always seems to think everyone who likes it is faking it. it should be an official fallacy.
    the "no true scotch, man" fallacy.
  • LudiousLudious It's hard out here for a conservative bronyRegistered User regular
    So apparently Sarah Jessica Parker is going to star in some offshoot "Wicked" style Oz movie that deals with a non central character of the Oz Story.

    It's called

    Horse of a Different Color

  • FeralFeral Who needs a medical license when you've got style? Registered User regular
    Anecdotally, specialists are more likely to work with you on off label stuff because specialists tend to be a little more technical in their prescriptions.

    GPs & PCPs are largely working by established medical practices.

    every person who doesn't like an acquired taste always seems to think everyone who likes it is faking it. it should be an official fallacy.
    the "no true scotch, man" fallacy.
  • ThomamelasThomamelas “Three films a day, three books a week and records of great music would be enough to make me happy to the day I die.” Registered User regular
    Thomamelas wrote: »
    Echo wrote: »
    DoctorArch wrote: »
    I really want to get the A-10 Warthog simulator on sale at Steam but I know I won't play it anytime soon. I just have such a huge mancrush on the A-10.

    "Here's a gun. Let's build an aircraft around it."

    As crazy as the A-10 is, I think the design meeting for the AC-130H tops it. "Fuck it, we've got some 105mm howitzers sitting around, lets put one of those on a fucking plane!"

    the way the A-10 turned out though is one of the bigger successes of military hardware. Those things are cheap to build, actually acomplish a needed role (close ground support as opposed to stupid shit like air superiority fighters) and are extrememly tough and well armored.

    If it weren't for stupid funding rules designed to keep the services from spending all their time sabotaging each other they should replace every attack helicoper in service with an A10.

    There are a couple of roles that some of the attack choppers can do better. Scouting and spotting roles mostly.

  • ThanatosThanatos Registered User regular
    Ludious wrote: »
    Thanatos wrote: »
    Ludious wrote: »
    No Than. My agency is the bastard child of the government. We're governed under an entirely separate Act (literally) that allows employees to be treated like shit basically.
    Have you started looking for a new job yet?

    Seriously, I wouldn't wait out the end of that one. It's going to be way harder to find another job once you're not employed anymore, and if they are left hanging because you live, you can explain to them exactly why in your exit interview. At this point, you owe them nothing.
    I'm not. I'm doing everything I can but I'm in the nasty position of get a job making what I make or take a paycut and lose my house, sooooooo. I already have some contacts with some I.T. contractors. I have a plan B. Basically if I lose my job I can do contract work in Atlanta until I can find a job. I have a contingency plan. But I'm not going to walk away from a GS-12 job for less money just to lose my house and fuck up my credit. I'm in a damned if I do, damned if I don't situation. Which is why I was shocked when I was lead to believe I'd get my CCNA. It combined with my Security+ and Network+ and 7 years of federal experience would have helped the fuck out of my job seeking and value. And it's not like it was my fucking idea.
    Yeah, that's some shit.

  • surrealitychecksurrealitycheck NONSTOP INFINITE CLIMAX POSTING you must go on i cant go on ill go onRegistered User regular
    also, people dont abuse naltrexone

    I GET TOO HIGH SOMETIMES YOU GOTTA GET ME DAT NALTREXONE DAWG

    so he should give you zero shit

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  • WinkyWinky Frog Rammer Registered User regular
    Well, I mean, most of these are like just chemical compounds they have injected into rats before.

    This wouldn't stop me from using them, of course.

    Play Super Smush wit me: 1006-0814-0691
This discussion has been closed.