Ok so well, this is my friend's computer. AFAIK it runs Windows XP SP3. He's got a 250GB SATA drive on it and probably another IDE one.
The problem started when he installed Kaspersky and tried to pirate it. He got a "This key has been blacklisted" message, and he says that the program simply decided not to protect him from the internet, but the antivirus remained active.
Now the problem is that his computer is denying any writing to the C: drive. Whenever he tries to copy or create anything on C:, he gets a message that his HDD is full, yet he still has 16GB free on it. Uninstalling programs also denies any access to C:, so basically he's been locked out of doing anything to C:
His other partition works just fine. A full scan reveals nothing. Is this a common problem? I've told him to make a new user account and see if that helps, haven't received a response yet.
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Your solution is the most obvious but... He can't uninstall/install anything.