Options

Another Brick in the [chat]

1679111247

Posts

  • Options
    GreeperGreeper Registered User regular
    edited February 2008
    God man! Don't overdo it.

    You tried. You tried. Let none say you did not try. That is all we could have asked of you.

    Greeper on
  • Options
    Zen VulgarityZen Vulgarity What a lovely day for tea Secret British ThreadRegistered User regular
    edited February 2008
    Poooodddsssss

    Zen Vulgarity on
  • Options
    JamesKeenanJamesKeenan Registered User regular
    edited February 2008
    You should make a recording and post it somewhere we can hear.

    Somewhere like Youtube.

    JamesKeenan on
  • Options
    IreneDAdlerIreneDAdler Registered User regular
    edited February 2008
    DIE YOU FUCKING PIECE OF SHIT PAPER DIE!!!!

    IreneDAdler on
    [SIGPIC][/SIGPIC]
  • Options
    SenjutsuSenjutsu thot enthusiast Registered User regular
    edited February 2008
    DERE TAKIN OR JERBBBSSS

    Senjutsu on
  • Options
    JamesKeenanJamesKeenan Registered User regular
    edited February 2008
    DIE YOU FUCKING PIECE OF SHIT PAPER DIE!!!!

    24 hours from now:


    IreneDAdler: "This isn't Irene. I just came on here to tell you that Irene was institutionalized last night. I know, however, she would have wanted you guys to know... Before, of course, she went batshit crazy and started pouring sulphuric acid over all the loose leaf notebooks in the house, then tried to burn all the trees in our neighborhood down, shouting, 'get the fuckers before it starts.' Sorry to break the news like this. Have a good day."

    JamesKeenan on
  • Options
    questionabledudequestionabledude Registered User regular
    edited February 2008
    DIE YOU FUCKING PIECE OF SHIT PAPER DIE!!!!

    I find your anger... arousing.

    I'm not voting for Hilary because women belong in the kitchen and laundry room.

    questionabledude on
  • Options
    TehSpectreTehSpectre Registered User regular
    edited February 2008
    I kind of want to make a thread about the new Wolverine movie now that an extended cast list has been revealed.

    I mean, Danny Houston as a younger William Stryker is awesome and all, but a rumor that Ryan Reynolds is going to play Deadpool is the clincher.

    Also Gambit.

    I am offically excited about the movie now.

    TehSpectre on
    9u72nmv0y64e.jpg
  • Options
    TehSpectreTehSpectre Registered User regular
    edited February 2008
    Senjutsu wrote: »
    DERE TAKIN OR JERBBBSSS

    DEY TOOKER DERBS

    TehSpectre on
    9u72nmv0y64e.jpg
  • Options
    questionabledudequestionabledude Registered User regular
    edited February 2008
    DIE YOU FUCKING PIECE OF SHIT PAPER DIE!!!!

    24 hours from now:


    IreneDAdler: "This isn't Irene. I just came on here to tell you that Irene was institutionalized last night. I know, however, she would have wanted you guys to know... Before, of course, she went batshit crazy and started pouring sulphuric acid over all the loose leaf notebooks in the house, then tried to burn all the trees in our neighborhood down, shouting, 'get the fuckers before it starts.' Sorry to break the news like this. Have a good day."

    This is the first time I actually made a spit take because of something I read on the internet. You owe me a keyboard, like on Fark. Someone's gotta sig that. Will it be... me?

    questionabledude on
  • Options
    questionabledudequestionabledude Registered User regular
    edited February 2008
    TehSpectre wrote: »
    Senjutsu wrote: »
    DERE TAKIN OR JERBBBSSS

    DEY TOOKER DERBS

    DUR DUR DEEERG

    questionabledude on
  • Options
    JamesKeenanJamesKeenan Registered User regular
    edited February 2008
    TehSpectre wrote: »
    I kind of want to make a thread about the new Wolverine movie now that an extended cast list has been revealed.

    I mean, Danny Houston as a younger William Stryker is awesome and all, but a rumor that Ryan Reynolds is going to play Deadpool is the clincher.

    Also Gambit.

    I am offically excited about the movie now.

    Will you be in it? Wait, no... no.

    You're in Fantastic Four.

    JamesKeenan on
  • Options
    SenjutsuSenjutsu thot enthusiast Registered User regular
    edited February 2008
    I love that they become progressively more incoherent

    Senjutsu on
  • Options
    Zen VulgarityZen Vulgarity What a lovely day for tea Secret British ThreadRegistered User regular
    edited February 2008
    AHHH FUCK

    I RIPPED THEM WITHOUT THE INFO

    Zen Vulgarity on
  • Options
    Ethan SmithEthan Smith Origin name: Beart4to Arlington, VARegistered User regular
    edited February 2008
    DE DOOKDUR DURBS!

    Ethan Smith on
  • Options
    GreeperGreeper Registered User regular
    edited February 2008
    ALL ILLEGAL IMMEGRANTS ARE BAD PEOPLE AND YOU SHOULD FEEL BAD.

    Greeper on
  • Options
    JamesKeenanJamesKeenan Registered User regular
    edited February 2008
    DIE YOU FUCKING PIECE OF SHIT PAPER DIE!!!!

    24 hours from now:


    IreneDAdler: "This isn't Irene. I just came on here to tell you that Irene was institutionalized last night. I know, however, she would have wanted you guys to know... Before, of course, she went batshit crazy and started pouring sulphuric acid over all the loose leaf notebooks in the house, then tried to burn all the trees in our neighborhood down, shouting, 'get the fuckers before it starts.' Sorry to break the news like this. Have a good day."

    This is the first time I actually made a spit take because of something I read on the internet. You owe me a keyboard, like on Fark. Someone's gotta sig that. Will it be... me?

    It's a bit big... you'd probably just get in trouble, and it would be all my fault... Shit, I already feel guilty about the trouble I could have caused, and responsible for your inevitable disappointment...

    And it's not really that funny.
    ok it totally is im hilarious

    JamesKeenan on
  • Options
    IncenjucarIncenjucar VChatter Seattle, WARegistered User regular
    edited February 2008
    Greeper wrote: »
    ALL ILLEGAL IMMEGRANTS ARE BAD PEOPLE AND YOU SHOULD FEEL BAD.

    Agreed.

    Damned Europeans, all crossing the border onto Native American land.

    Incenjucar on
  • Options
    questionabledudequestionabledude Registered User regular
    edited February 2008
    I wonder if any illegal immigrants post in PA.

    Will you take my job? Please?

    questionabledude on
  • Options
    IreneDAdlerIreneDAdler Registered User regular
    edited February 2008
    I don't mean paper as in processed tree carcasses, I mean paper as in journal paper, as in this piece of shit on endocytosis I have to read and present in class tomorrow.

    IreneDAdler on
    [SIGPIC][/SIGPIC]
  • Options
    IncenjucarIncenjucar VChatter Seattle, WARegistered User regular
    edited February 2008
    I wonder if any illegal immigrants post in PA.

    Will you take my job? Please?

    No, that's TATA's job now.

    Incenjucar on
  • Options
    SenjutsuSenjutsu thot enthusiast Registered User regular
    edited February 2008
    I don't mean paper as in processed tree carcasses, I mean paper as in journal paper, as in this piece of shit on endocytosis I have to read and present in class tomorrow.

    You just have to pep it up

    Endocytosis: IT'S NOT LUPUS, BITCHES

    Senjutsu on
  • Options
    DynagripDynagrip Break me a million hearts HoustonRegistered User, ClubPA regular
    edited February 2008
    Good game, good game.

    Dynagrip on
  • Options
    questionabledudequestionabledude Registered User regular
    edited February 2008
    The tree part really adds the final touch:

    'get the fuckers before it starts.'

    I'm just gonna sig that and make people wonder about the context.

    questionabledude on
  • Options
    OboroOboro __BANNED USERS regular
    edited February 2008
    I have achieved satisfaction

    a great beast of history has been quelled

    Oboro on
    words
  • Options
    JamesKeenanJamesKeenan Registered User regular
    edited February 2008
    Here. Change the words around a bit, and I just wrote your paper for you.
    Endocytosis
    From Wikipedia, the free encyclopedia
    Jump to: navigation, search
    It has been suggested that Trans-endocytosis be merged into this article or section. (Discuss)

    Endocytosis is a process where cells absorb material (molecules such as proteins) from the outside by engulfing it with their cell membrane. It is used by all cells of the body because most substances important to them are large polar molecules, and thus cannot pass through the hydrophobic plasma membrane. The function of endocytosis is the opposite of exocytosis.
    Contents
    [hide]

    * 1 Types
    * 2 Endocytosis pathways
    * 3 Clathrin-mediated endocytosis
    * 4 See also
    * 5 External links

    [edit] Types
    different forms of Endocytosis
    different forms of Endocytosis

    The absorption of material from the outside environment of the cell is commonly divided into two processes: phagocytosis and pinocytosis.

    * Phagocytosis (literally, cell-eating) is the process by which cells ingest large objects, such as cells which have undergone apoptosis, bacteria, or viruses. The membrane folds around the object, and the object is sealed off into a large vacuole known as a phagosome.

    * Pinocytosis (literally, cell-drinking) is a synonym for endocytosis. This process is concerned with the uptake of solutes and single molecules such as proteins.

    * Receptor-mediated endocytosis is a more specific active event where the cytoplasm membrane folds inward to form coated pits. These inward budding vesicles bud to form cytoplasmic vesicles.

    [edit] Endocytosis pathways

    There are three types of endocytosis: namely, macropinocytosis, clathrin-mediated endocytosis, and caveolar endocytosis.

    * Macropinocytosis is the invagination of the cell membrane to form a pocket, which then pinches off into the cell to form a vesicle filled with extracellular fluid (and molecules within it). The filling of the pocket occurs in a non-specific manner. The vesicle then travels into the cytosol and fuses with other vesicles such as endosomes and lysosomes.

    * Clathrin-mediated endocytosis is the specific uptake of large extracellular molecules such as proteins, membrane localized receptors and ion-channels. These receptors are associated with the cytosolic protein clathrin, which initiates the formation of a vesicle by forming a crystalline coat on the inner surface of the cell's membrane.

    * Caveolae consist of the protein caveolin-1 with a bilayer enriched in cholesterol and glycolipids. Caveolae are flask-shape pits in the membrane that resemble the shape of a cave (hence the name caveolae). Uptake of extracellular molecules are also believed to be specifically mediated via receptors in caveolae.

    [edit] Clathrin-mediated endocytosis

    The major route for endocytosis in most cells, and the best-understood, is that mediated by the molecule clathrin. This large protein assists in the formation of a coated pit on the inner surface of the plasma membrane of the cell. This pit then buds into the cell to form a coated vesicle in the cytoplasm of the cell. In so doing, it brings into the cell not only a small area of the surface of the cell but also a small volume of fluid from outside the cell.

    Vesicles selectively concentrate and exclude certain proteins during formation and are not representative of the membrane as a whole. AP2 adaptors are multisubunit complexes that perform this function at the plasma membrane. The best-understood receptors that are found concentrated in coated vesicles of mammalian cells are the LDL receptor (which removes LDL from the blood circulation), the transferrin receptor (which brings ferric ions bound by transferrin into the cell) and certain hormone receptors (such as that for EGF).

    At any one moment, about 2% of the plasma membrane of a fibroblast is made up of coated pits. As a coated pit has a life of about a minute before it buds into the cell, a fibroblast takes up its surface by this route about once every 50 minutes. Coated vesicles formed from the plasma membrane have a diameter of about 100nm and a lifetime measured in a few seconds. Once the coat has been shed, the remaining vesicle fuses with endosomes and proceeds down the endocytic pathway. The actual budding-in process, whereby a pit is converted to a vesicle, is carried out by clathrin assisted by a set of cytoplasmic proteins, which includes dynamin and adaptors such as adaptin.

    Coated pits and vesicles were first seen in thin sections of tissue in the electron microscope by Thomas Roth and Keith Porter in 1964. The importance of them for the clearance of LDL from blood was discovered by R. G Anderson, Michael S. Brown and Joseph L. Goldstein in 1976. Coated vesicles were first purified by Barbara Pearse, who discovered the clathrin coat molecule, also in 1976.

    [edit] See also

    * Exocytosis

    [edit] External links

    * Endocytosis at biologyreference.com
    * Endocytosis - researching endocytic mechanisms at endocytosis.org

    [hide]
    v • d • e
    Membrane transport
    Passive transport Diffusion - Facilitated diffusion - Osmosis
    Active transport Primary active transport - Secondary active transport
    -cytosis Exocytosis - Endocytosis (Phagocytosis, transcytosis, fluid-phase pinocytosis, non-specific, adsorptive pinocytosis)
    Retrieved from "http://en.wikipedia.org/wiki/Endocytosis"

    Categories: Articles to be merged since December 2007 | Cellular processes
    Views

    * Article
    * Discussion
    * Edit this page
    * History

    Personal tools

    * Log in / create account

    Navigation

    * Main Page
    * Contents
    * Featured content
    * Current events
    * Random article

    Interaction

    * About Wikipedia
    * Community portal
    * Recent changes
    * Contact Wikipedia
    * Donate to Wikipedia
    * Help

    Search

    Toolbox

    * What links here
    * Related changes
    * Upload file
    * Special pages
    * Printable version
    * Permanent link
    * Cite this page

    Languages

    * Česky
    * Español
    * Français
    * עברית
    * Magyar
    * Nederlands
    * 日本語
    * ‪Norsk (bokmÃ¥l)‬
    * Polski
    * Português
    * SlovenÅ¡čina
    * Српски / Srpski
    * Suomi
    * Svenska
    * Türkçe

    Powered by MediaWiki
    Wikimedia Foundation

    * This page was last modified on 11 February 2008, at 17:58.
    * All text is available under the terms of the GNU Free Documentation License. (See Copyrights for details.)
    Wikipedia® is a registered trademark of the Wikimedia Foundation, Inc., a U.S. registered 501(c)(3) tax-deductible nonprofit charity.
    * Privacy policy
    * About Wikipedia
    * Disclaimers

    JamesKeenan on
  • Options
    GooeyGooey (\/)┌¶─¶┐(\/) pinch pinchRegistered User regular
    edited February 2008
    Dynagrip wrote: »
    Good game, good game.

    I'm so glad we didn't start over.

    Holding blue off like that was so much fun.

    Gooey on
    919UOwT.png
  • Options
    TehSpectreTehSpectre Registered User regular
    edited February 2008
    Will you be in it? Wait, no... no.

    You're in Fantastic Four.

    Yousonofabitch.

    TehSpectre on
    9u72nmv0y64e.jpg
  • Options
    Ethan SmithEthan Smith Origin name: Beart4to Arlington, VARegistered User regular
    edited February 2008
    TehSpectre wrote: »
    Will you be in it? Wait, no... no.

    You're in Fantastic Four.

    Yousonofabitch.

    Don't blame me, after all

    YOU MARRIED HER

    carrey58.jpeg

    God that movie was so good

    Ethan Smith on
  • Options
    ElkiElki get busy Moderator, ClubPA Mod Emeritus
    edited February 2008
    Sharper Image is going bankrupt. Hooray!

    Elki on
    smCQ5WE.jpg
  • Options
    Zen VulgarityZen Vulgarity What a lovely day for tea Secret British ThreadRegistered User regular
    edited February 2008
    Why are you so happy?

    Zen Vulgarity on
  • Options
    JamesKeenanJamesKeenan Registered User regular
    edited February 2008
    Jobs will be lost?

    JamesKeenan on
  • Options
    questionabledudequestionabledude Registered User regular
    edited February 2008
    Damn goobacks!

    questionabledude on
  • Options
    SenjutsuSenjutsu thot enthusiast Registered User regular
    edited February 2008
    Why are you so happy?

    'cause that place is retarded and sells junk

    Senjutsu on
  • Options
    ElkiElki get busy Moderator, ClubPA Mod Emeritus
    edited February 2008
    I think it reflects well on America. Just a bit.

    Elki on
    smCQ5WE.jpg
  • Options
    Zen VulgarityZen Vulgarity What a lovely day for tea Secret British ThreadRegistered User regular
    edited February 2008
    Well, I don't like to think about people losing their jobs as a good thing all the time.

    I'm not free market enough.

    Zen Vulgarity on
  • Options
    Loren MichaelLoren Michael Registered User regular
    edited February 2008
    God damn it, I'm bored.

    I wish classes started this week instead of next.

    Loren Michael on
    a7iea7nzewtq.jpg
  • Options
    DynagripDynagrip Break me a million hearts HoustonRegistered User, ClubPA regular
    edited February 2008
    Gooey wrote: »
    Dynagrip wrote: »
    Good game, good game.

    I'm so glad we didn't start over.

    Holding blue off like that was so much fun.
    I think I fucked myself for a bit there by changing up my normal research strategy. My economy was great and all until they snagged a planet from my feeble grasp.

    Dynagrip on
  • Options
    JamesKeenanJamesKeenan Registered User regular
    edited February 2008
    How's it retarded? It's not selling, like... shoes to prevent you from falling off Earth when you visit Australia, or anything...

    JamesKeenan on
  • Options
    DynagripDynagrip Break me a million hearts HoustonRegistered User, ClubPA regular
    edited February 2008
    No, Sharper Image is in fact retarded.

    Dynagrip on
This discussion has been closed.