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Biochemistry Question

borzou99borzou99 Registered User, ClubPA regular
edited December 2008 in Help / Advice Forum
When making phosphatidyl serine via condensation reaction, does the serine lose its -OH or the phosphate?

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    RookRook Registered User regular
    edited December 2008
    Probably depends on how you make it, but going from first principles. What do you think is more likely to exist as an R-OH, the phosphate or the alcohol? (there might be a slight clue in the name).

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    borzou99borzou99 Registered User, ClubPA regular
    edited December 2008
    My friend and I were debating this point, but unfortunately I don't have my science texts on me. I thought it would be serine that loses it's hydroxyl.

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    DarkewolfeDarkewolfe Registered User regular
    edited December 2008
    So... phosphate doesn't have a hydroxide group while serine does, right?

    Darkewolfe on
    What is this I don't even.
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    Fuzzy Cumulonimbus CloudFuzzy Cumulonimbus Cloud Registered User regular
    edited December 2008
    Phosphates dont normally have protonated edges, do they?

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    RookRook Registered User regular
    edited December 2008
    Fuzzy Cumulonimbus Cloud wrote: »
    Phosphates dont normally have protonated edges, do they?

    Not unless you're in a really acidic environment, and certainly not when compared to alcohol side chains.

    I mean my straight up answer is I don't know, and I thought generally phosphatidyl serine was made from converting other phospholipids or through CDP-diglyceride. But if you just had a vat of serine and phosphatic acid and mixing them together, then that's probably what happens.

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