This one's weird. Recently my computer has started hard-locking for reasons I haven't quite figured it out. It often happens when playing media of some kind and I figured maybe it was Flash, so I updated Flash, and things worked for a little while but then my mouse stopped clicking. Like, none of the buttons register, but the mouse otherwise works fine. I can hover over things and... that's it. Even the sensitivity adjustment buttons don't do anything. It's a Logitech G500s and I'm running Windows 7, and when I boot into Safe Mode or boot up the other older Win 7 install I've got on this computer, it works totally fine. The device manager doesn't see anything weird. Unplugging + plugging back in did nothing. I did a System Restore to a few Windows updates ago (February 4th) which also took away the new Flash update and that didn't help. I Googled a bit and people have suggested everything from updating video drivers to even crazier stuff. Has anyone ever run into this?
edit: the plot thickens - I made a new user account and the mouse works fine there...
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Reinstall the mouse drivers.