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Obesity "Master switch" found

RoeRoe Always to the EastRegistered User regular
edited May 2011 in Debate and/or Discourse
According Yahoo news, scientists have found the gene that is linked to family obesity and diseases such as heart disease and diabetes.

http://news.yahoo.com/s/nm/20110515/lf_nm_life/us_obesity_genes

This could change heart medicine as we know it. Perhaps cut down on heart problems for the next generation.

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Roe on
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Posts

  • RobmanRobman Registered User regular
    edited May 2011
    The odds of this providing any therapeutic value are vanishingly small. Also, so-called "master gene" theories pop up all the time, only to fall to the wayside when people discover miRNA that controls the so-called "master gene" from another pathway previously thought to be unrelated.

    Robman on
  • override367override367 ALL minions Registered User regular
    edited May 2011
    I don't see anything at that link, but my brain has an automatic yahoo news filter so that could be to blame

    Edit: got it, yea Robman's pretty much got it

    override367 on
  • ElJeffeElJeffe Registered User, ClubPA regular
    edited May 2011
    What Robman said.

    ElJeffe on
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  • EchoEcho ski-bap ba-dapModerator, Administrator admin
    edited May 2011
    Robman wrote: »
    The odds of this providing any therapeutic value are vanishingly small. Also, so-called "master gene" theories pop up all the time, only to fall to the wayside when people discover miRNA that controls the so-called "master gene" from another pathway previously thought to be unrelated.

    A while back I read about some study that found a link between a creature having fur and a... spiked penis. The controls for a spiked penis on the male of the species also resulted in fur.

    edit: randomly googled link

    edit edit: ok, it wasn't fur, but close enough.
    When these chimpanzee sequences were inserted into mouse embryos, the mice developed both the hard penile spines and sensory whiskers present in some animals.

    Echo on
  • RobmanRobman Registered User regular
    edited May 2011
    Oh great, now I'm going to think of porcupenis chimps when I have to go by the transgenics labs at work.

    Robman on
  • Caveman PawsCaveman Paws Registered User regular
    edited May 2011
    Robman wrote: »
    Oh great, now I'm going to think of porcupenis chimps when I have to go by the transgenics labs at work.

    Won't someone please think of the pocupenis chimp children?

    On topic (more so): Alot of science blogs and sites have very sensational article titles, and after you click thinking the cure for (whatever) is at last upon us, no, it's not even close.

    Caveman Paws on
  • RobmanRobman Registered User regular
    edited May 2011
    CLICKS FOR THE CLICK GOD

    Science blogging is fundamentally a niche market for a niche audience. In order to drive up general views, we get "SCIENTISTS FIND FAT GENE" rather then "RK229 PLASMID TRANSFECTED SPRAGUE-DAWLEY RATS DEVELOP LESS ADIPOSE TISSUE UNDER STANDARD DIET CONDITIONS COMPARED TO CONTROLS"

    edit: details in the above paragraph are illustrative of the issue, not the paper in question

    Robman on
  • DrezDrez Registered User regular
    edited May 2011
    Wait, are spiked penises uncommon or something?

    ...

    Drez on
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  • Caveman PawsCaveman Paws Registered User regular
    edited May 2011
    Drez wrote: »
    Wait, are spiked penises uncommon or something?

    ...

    Only your middle penis should be spiked, why do you ask?

    Caveman Paws on
  • HenroidHenroid Mexican kicked from Immigration Thread Centrism is Racism :3Registered User regular
    edited May 2011
    I'm sure it could produce a major step in the direction of handling heart disease and obesity, but if there's anything I learned in life it's that silver bullets don't actually exist. I mean, in a metaphorical sense.

    Henroid on
  • zerg rushzerg rush Registered User regular
    edited May 2011
    Anyone remember that super-rat gene, which could cause rats to run 20 kilometers without stopping, never get fat, and let rats in advanced old age give birth? Yeah, it's been a while.


    I have a feeling this discovery is going to end up with that one.

    zerg rush on
  • BagginsesBagginses __BANNED USERS regular
    edited May 2011
    Henroid wrote: »
    I'm sure it could produce a major step in the direction of handling heart disease and obesity, but if there's anything I learned in life it's that silver bullets don't actually exist. I mean, in a metaphorical sense.

    What about the smallpox and rinderpest vaccines?

    Bagginses on
  • HenroidHenroid Mexican kicked from Immigration Thread Centrism is Racism :3Registered User regular
    edited May 2011
    Bagginses wrote: »
    Henroid wrote: »
    I'm sure it could produce a major step in the direction of handling heart disease and obesity, but if there's anything I learned in life it's that silver bullets don't actually exist. I mean, in a metaphorical sense.

    What about the smallpox and rinderpest vaccines?

    I was expecting someone to say, "What about werewolves?" but yeah okay.

    Henroid on
  • Anarchy Rules!Anarchy Rules! Registered User regular
    edited May 2011
    It's an interesting enough development, but whenever an article mentions a single 'master-switch' or gene, take it with a pinch of salt.

    Often, it's a valid piece of primary research, but the newspapers generally make it seem like a big thing, when science is more a slow progression.

    The NHS has a pretty good website in which newspaper articles are assessed on the validity of their statements, it's generally quite interesting. Link

    Anarchy Rules! on
  • RMS OceanicRMS Oceanic Registered User regular
    edited May 2011
    This is more a Vesalius or a Harvey than a Pare.

    Explaination: When studying history of medicine, these are three Rennaisance doctors we study. Vesalius and Harvey added to the knowledge of anatomy, Harvey in particular learning about the heart and the circulatory system. This knowledge is undoubtedly useful in our time, but it didn't have much of an impact at the time. Pare was a surgeon who devised a number of measures to improve surgical survival rates, so his knowledge was much more immediately applicable.

    In conclusion, this information will be useful, but not yet, and not for the reason of a magic bullet.

    RMS Oceanic on
  • The Black HunterThe Black Hunter The key is a minimum of compromise, and a simple, unimpeachable reason to existRegistered User regular
    edited May 2011
    I thought it was the "providing absolutely no food education to your children" gene

    The Black Hunter on
  • Lord JezoLord Jezo Registered User regular
    edited May 2011
    "KLF14 seems to act as a master switch controlling processes that connect changes in the behavior of subcutaneous fat to disturbances in muscle and liver that contribute to diabetes and other conditions," said Mark McCarthy from Britain's Oxford University, who also worked on the study.

    This sounds like a gene that controls the way fat is handled in the body once it's consumed and nothing to do with getting fat people to control themselves and put down the cake.

    Lord Jezo on
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  • bowenbowen Sup? Registered User regular
    edited May 2011
    This just in: Genes are not static.

    bowen on
    not a doctor, not a lawyer, examples I use may not be fully researched so don't take out of context plz, don't @ me
  • armageddonboundarmageddonbound Registered User regular
    edited May 2011
    If these fabulous headlines ever bear fruit, in say 50 years. Imagine what the difference would be between the haves (healthcare) and the have nots (poor healthcare).

    armageddonbound on
  • RMS OceanicRMS Oceanic Registered User regular
    edited May 2011
    Lord Jezo wrote: »
    "KLF14 seems to act as a master switch controlling processes that connect changes in the behavior of subcutaneous fat to disturbances in muscle and liver that contribute to diabetes and other conditions," said Mark McCarthy from Britain's Oxford University, who also worked on the study.

    This sounds like a gene that controls the way fat is handled in the body once it's consumed and nothing to do with getting fat people to control themselves and put down the cake.

    It's more a hypothetical way to avoid some of the negative health consequences of obesity, than avoiding obesity itself.

    But as Bowen said, genetics isn't that simple.

    RMS Oceanic on
  • Rhan9Rhan9 Registered User regular
    edited May 2011
    If these fabulous headlines ever bear fruit, in say 50 years. Imagine what the difference would be between the haves (healthcare) and the have nots (poor healthcare).

    Canada, as well as parts of Europe(especially in the north) and Japan will be full of healthier people than places like the U.S. which has great healthcare, if you're rich, while these other places attempt to offer it to most of the population. That is, if it actually happened like you suggested.

    Rhan9 on
  • Skoal CatSkoal Cat Registered User regular
    edited May 2011
    Wait, so scientists discovered sugar?

    Skoal Cat on
  • azith28azith28 Registered User regular
    edited May 2011
    Honestly we are so far off from any kind of realistic safe gene therapy/ modification that this means very little.

    Sure its good knowledge for when we do...but I think nanites need to be a realistic medical tool before this will help.

    azith28 on
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  • corcorigancorcorigan Registered User regular
    edited May 2011
    I wish they'd link to the bloody studies. How is anyone supposed to get any real information from a news article like that?

    Anyway, it's more likely a research group trying to get some publicity and therefore a better chance of getting more funding that anything dramatic. Fortunately there's still eating properly, or if that's proving difficult, surgery.

    corcorigan on
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  • YarYar Registered User regular
    edited May 2011
    Wait... you guys' penises aren't spiked?

    Yar on
  • VishNubVishNub Registered User regular
    edited May 2011
    They also never actually link the original article anywhere that anyone can find it. Which is annoying.

    And while there may be a valid protein target arising from this gene, it's unlikely that any reasonable therapy will be developed.

    Also the fail rate for anti-obesity drugs is almost as high as for new antibiotics, which is remarkable.

    VishNub on
  • corcorigancorcorigan Registered User regular
    edited May 2011
    Not to mention all the suicides and anal leakage.

    corcorigan on
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  • RobmanRobman Registered User regular
    edited May 2011
    I gotta say though, it's not like we don't already know a conservative cure and management regime for obesity that works for 99% of compliant patients. Most antibiotic regimes can't boast that success rate.

    Robman on
  • themightypuckthemightypuck MontanaRegistered User regular
    edited May 2011
    Robman wrote: »
    I gotta say though, it's not like we don't already know a conservative cure and management regime for obesity that works for 99% of compliant patients. Most antibiotic regimes can't boast that success rate.

    No kidding. We have similar ways to prevent unwanted pregnancies and STDs.

    themightypuck on
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  • RobmanRobman Registered User regular
    edited May 2011
    That's a bad comparison and you know it. You can eat healthy food that is tastier and cheaper then the unhealthy crap. If you want to have sex, you have to either risk babby or STDs, or deal with the condoms.

    People only use condoms because aids and babies are worse.

    Robman on
  • FeralFeral MEMETICHARIZARD interior crocodile alligator ⇔ ǝɹʇɐǝɥʇ ǝᴉʌoɯ ʇǝloɹʌǝɥɔ ɐ ǝʌᴉɹp ᴉRegistered User regular
    edited May 2011
    Robman wrote: »
    I gotta say though, it's not like we don't already know a conservative cure and management regime for obesity that works for 99% of compliant patients. Most antibiotic regimes can't boast that success rate.

    99% of the time, it works 50% of the time.

    Feral on
    every person who doesn't like an acquired taste always seems to think everyone who likes it is faking it. it should be an official fallacy.

    the "no true scotch man" fallacy.
  • FeralFeral MEMETICHARIZARD interior crocodile alligator ⇔ ǝɹʇɐǝɥʇ ǝᴉʌoɯ ʇǝloɹʌǝɥɔ ɐ ǝʌᴉɹp ᴉRegistered User regular
    edited May 2011
    In any case, citing the success rate as 99% is a vast overstatement. It depends on what your goalposts are, but most studies consider successful long-term weight-loss to involve a reduction in weight of 10% maintained over one year. Even at that modest threshold, roughly 20% of patients are successful at it through lifestyle modification alone.

    And of course, that's not looking at whether or not a loss of 10% of body weight puts you in a normal weight range. If you go from 30 to 27 on the BMI, you're still overweight.

    And you can't just hand-wave away compliance issues because (1) very few weight-loss studies actually track compliance separately from results, so you can't actually say that those who failed were non-compliant and (2) compliance in weight-loss isn't as simple as taking a pill every day.

    Feral on
    every person who doesn't like an acquired taste always seems to think everyone who likes it is faking it. it should be an official fallacy.

    the "no true scotch man" fallacy.
  • ImriayldeImriaylde Registered User regular
    edited May 2011
    Robman wrote: »
    That's a bad comparison and you know it. You can eat healthy food that is tastier and cheaper then the unhealthy crap. If you want to have sex, you have to either risk babby or STDs, or deal with the condoms.

    People only use condoms because aids and babies are worse.

    Fast food is cheaper and far more convenient than most things, and some people just really enjoy that deep-fried taste. Eating healthy can be very expensive or very time consuming if it's being prepared from scratch, and the prevalence of fast food joints doesn't make it any easier. I'm not saying you're wrong and that it's impossible to eat healthy - of course it isn't - but to make a blanket statement that healthy food is cheaper and tastes better overall than unhealthy food isn't true. I remember checking out that Spent game a few months back - it was the one where you had to see if you could live in poverty for a month - and one of your options was either a $6 salad or a $1 burger. Sometimes people need to decide between counting pennies and counting calories.

    Imriaylde on
  • corcorigancorcorigan Registered User regular
    edited May 2011
    From what I gather losing weight conservatively fails ultimately in practically all very overweight persons.

    Hence surgery.

    corcorigan on
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  • FeralFeral MEMETICHARIZARD interior crocodile alligator ⇔ ǝɹʇɐǝɥʇ ǝᴉʌoɯ ʇǝloɹʌǝɥɔ ɐ ǝʌᴉɹp ᴉRegistered User regular
    edited May 2011
    corcorigan wrote: »
    From what I gather losing weight conservatively fails ultimately in practically all very overweight persons.

    Hence surgery.

    Right. People will say "anybody can lose weight" and that's strictly true, but it's also largely irrelevant. Losing weight isn't the goal, maintaining a target weight is the goal. If you look at people who are very overweight over a long period of time, it is exceedingly rare for very overweight people to attain and maintain a normal weight.

    That said, even with surgery, most of the time physicians will want to see some weight loss first. This is largely because after any kind of bariatric surgery, the patient will be required to adhere to a special diet. (Some surgeries are stricter than others regarding what and when and how much you can eat after the surgery.) You need to prove that you can actually control your own food intake before it's safe to do surgery.

    Feral on
    every person who doesn't like an acquired taste always seems to think everyone who likes it is faking it. it should be an official fallacy.

    the "no true scotch man" fallacy.
  • BurtletoyBurtletoy Registered User regular
    edited May 2011
    VishNub wrote: »
    They also never actually link the original article anywhere that anyone can find it. Which is annoying.

    And while there may be a valid protein target arising from this gene, it's unlikely that any reasonable therapy will be developed.

    Also the fail rate for anti-obesity drugs is almost as high as for new antibiotics, which is remarkable.

    That is because those articles cost a lot of money.

    And, well, they aren't for everyone to read.

    Burtletoy on
  • OtarOtar Registered User regular
    edited May 2011
    pemieL wrote: »
    This is a big news for those who are suffering from diabetes and obesity. A team of scientists in London have reported the gene KLF14 - known to be linked to Type 2 diabetes and cholesterol levels - is in fact a “master switch” gene.KFL14 determines the behavior of other genes found in body fat.This discovery can result in good breakthroughs in the treatment of Type 2 diabetes and other diseases associated with obesity. The proof is here: Gene found to control obesity and diabetes.

    Great now that you have a posted a link to a story identical to the one found in the OP you can read the rest of the topic now?

    Otar on
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  • YallYall Registered User regular
    edited May 2011
    I have always assumed that the obesity master switch was the one connected to the "open" sign at McDonalds.

    Sorry, had to do it. ;)

    Yall on
  • AtomikaAtomika Live fast and get fucked or whatever Registered User regular
    edited May 2011
    The really shocking thing to see is how much actual obesity is attributed to just ignorance.

    Biologically, some people are more predisposed to lifestyles and tastes that deter obesity, but obesity by and large is environmental and voluntary.



    A lot of that, though, can be chalked up to parenting that always taught us to "clean our plates" before dessert, and an FDA that conspired with Ag lobbies to flood the market with cheap carbs while lying to the public about how good it was for us.

    Atomika on
  • MalkorMalkor Registered User regular
    edited May 2011
    corcorigan wrote: »
    I wish they'd link to the bloody studies. How is anyone supposed to get any real information from a news article like that?

    Anyway, it's more likely a research group trying to get some publicity and therefore a better chance of getting more funding that anything dramatic. Fortunately there's still eating properly, or if that's proving difficult, surgery.

    You're not. Anytime I read a link to a science blog, I inevitable just Google the authors' names and hope that my old school's journal cataloging archive is still laughably open and relatively updated.

    Malkor on
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