What do you need to go about doing this? I want each monitor to be in their native resolution of 1920x1200, which ruled out the Matrox TrippleHead2Go device. My impulse guess was that three video cards would do the trick, but I've read some (out of date?) posts regarding the inability of SLI/Crossfire to support multiple screens. Is that true?
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Flight Sims and First Person Shooters come to mind.
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Fallout 3, Far Cry 2, GTA IV, and a ton of other triple-A titles released this year either failed to launch with SLI, or had broken SLI support at launch.
If you do manage it, a flightsim would most likely be your best bet. Whatever the most recent MS Flight Sim is would probably be a good place to start. Also, if I remember correctly, Windows 7's new graphics driver interface layer and Direct X 11 are supposed to do interesting things with SLI/Multiple GPU setups. Plus, 7 is rumored to be hitting as early as this June.
Best resource for widescreen and multiple monitor gaming.
I was just about to post this site. It is the source for wid4escreen gaming info.
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Every game with custom resolution will work. The game just won't know that uber high resolution will be outputted in 3 monitors, instead of a big single monitor. OS and graphic drivers take care of the work.
Intense, would be the word I would describe that experience.