(cross posted for your input)
I think it would encourage more gameplay and planning to have an inventory system where your inventory "levels up" alongside you.
* For example: at the beginning of the game, you could have access only to a few bandages, a bomb or two, and maybe one of each buff, but eventually after gaining a few levels, you get to store multiple buffs, debuffs, and other whatnots.
* Then, to go along with this, the inventories should be more like "per-encounter" powers in D&D4e and refill after every fight like the HP.
I found that before the last few encounters and final bosses in each Ep, I just ran back and forth between areas anyways, smashing open boxes to refill my inventory. It would be great if I could just bypass all that and just jump into a fight knowing that I'll have to be strategic in my item use.
What do you think?