I play WoW, so this may be a factor, as it's a rather large program, but I've been noticing some additional lag after starting up Pandora while playing. At first it's fine, but after one to a few hours, I notice the latency starts to pick up heavily. The key indicator for me is when I try to alt+tab between WoW and other programs, I basically lag bomb my pc.
Could this be something to do with Pandora?
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But just how much will running WoW for extended periods of time affect my CPU?
not really just the cpu. it effects a lot of stuff. over working your computer tends to do that
could even be the ram (which it probably is which is why it's making a difference when you run less things)
disable your start up items in msconfig and run only wow and pandora and you should be better off.
obviously nothing is going to run as good as just 1 app but if you take out the others in the background those 2 should run better
for now it seems your options are
play with both and run slower
play with one and not use pandora
lower resolution and test again